|
KMID : 1123920100240061027
|
|
Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 6 p.1027 ~ p.1033
|
|
|
Effects of Astragali Radix on Brain Edema and Apoptosis in Intracerebral Hemorrhage of Rats
|
|
Jung Hyung-Jin
Park Wan-Su
Kim Youn-Sub
|
|
|
Abstract
|
|
|
|
This study aimed to evaluate the effects of Astragali radix on brain edema of intracerebral hemorrhage(ICH)-induced rats. Brain edema following ICH was induced via the stereotaxic intrastriatal injection of bacterial collagenase type VII in Sprague-Dawley rats. Ethanol extract of Astragli radix was treated once a day for 3 days. Then brain hematoma volume and edema were examined. Immunohistochemistry was processed for iNOS, c-Fos, Bax, and HSP72 expressions in the brain sections and each immuno-labeling were calculated with image analysis. Ethanol extract of Astragli radix reduced hematoma volume(not significantly) and brain edema(significantly) ICH induced rats. Ethanol extract of Astragli radix reduced iNOS expressions, c-Fos, Bax and HSP72 positive cells significantly and reduced apoptotic bodies and swollen neurons in ICH induced rat brain. These results suggest that Astragli radix plays an inhibitory role in the hemorrhagic, inflammatory and apoptotic events induced by ICH. And it is supposed that neuroprotective effect of Astragli radix reveals by anti-apoptosis mechanism.
|
|
|
KEYWORD
|
|
|
Astragali radix, iNOS, c-Fos, Bax, HSP72
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|